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KMID : 0387820140210020168
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Clinical Pediatric Hematology-Oncology
2014 Volume.21 No. 2 p.168 ~ p.171
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Low Dose Methotrexate induced Bullous Acral Erythema in a Child with Acute Lymphoblastic Leukemia
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Cho So-Yeo
Lee Jae-Hee
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Abstract
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Chemotherapy-induced acral erythema (CIAE) is an uncommon, self-limited local skin reaction that usually occurs after high-dose chemotherapy. There is no specific treatment for this disease and it disappears within three to five weeks. In this case report, we present a 16-year-old female with acute lymphoblastic leukemia who developed severe CIAE. The lesions appeared as a well-defined erythema of the hands, feet, and back with symmetrically well-defined borders 5 days after low-dose MTX treatment. The eryth-ema progressed to bullae formation and desquamation. It resolved spontaneously within 2 weeks. CIAE is very uncommon in children; however we should consider acral eryth-ema as a differential diagnosis when bullous skin reaction occurs in a patient who re-ceives chemotherapy.
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KEYWORD
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Acral erythema, Chemotherapy side effect, Methotrexate
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